Community use of oral antibiotics transiently reprofiles the intestinal microbiome in young Bangladeshi children

Andrew Baldi; Sabine Braat; Mohammed Imrul Hasan; Cavan Bennett; Marilou Barrios; Naomi Jones; Gemma Moir-Meyer; Imadh Abdul Azeez; Stephen Wilcox; Mohammad Saiful Alam Bhuiyan; Ricardo Ataide; Danielle Clucas; Leonard C Harrison; Shams El Arifeen; Rory Bowden; Beverley-Ann Biggs; Aaron Jex; Sant-Rayn Pasricha

Journal article

Community use of oral antibiotics transiently reprofiles the intestinal microbiome in young Bangladeshi children

Andrew Baldi, Sabine Braat, Mohammed Imrul Hasan, Cavan Bennett, Marilou Barrios, Naomi Jones, Gemma Moir-Meyer, Imadh Abdul Azeez, Stephen Wilcox, Mohammad Saiful Alam Bhuiyan, Ricardo Ataide, Danielle Clucas, Leonard C Harrison, Shams El Arifeen, Rory Bowden, Beverley-Ann Biggs, Aaron Jex, Sant-Rayn Pasricha

Nature Communications | Nature Portfolio | Published : 2024

DOI: 10.1038/s41467-024-51326-5

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Abstract

Antibiotics may alter the gut microbiome, and this is one of the mechanisms by which antimicrobial resistance may be promoted. Suboptimal antimicrobial stewardship in Asia has been linked to antimicrobial resistance. We aim to examine the relationship between oral antibiotic use and composition and antimicrobial resistance in the gut microbiome in 1093 Bangladeshi infants. We leverage a trial of 8-month-old infants in rural Bangladesh: 61% of children were cumulatively exposed to antibiotics (most commonly cephalosporins and macrolides) over the 12-month study period, including 47% in the first 3 months of the study, usually for fever or respiratory infection. 16S rRNA amplicon sequencing in..

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University of Melbourne Researchers

Andrew Baldi Author

Sabine Braat Author

Cavan Bennett Author

Marilou Barrios Author

Related Projects (1)

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Awarded by Department of Health | National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

We thank the local field workers for their support, and all participants and their families for their involvement in the study. The authors gratefully acknowledge the WEHI Advanced Genomics Facility for their support and assistance in this work. This work was supported by the Australian National Health and Medical Research Council GNT1103262 (B.A.B.), GNT1159151 (S.P.), GNT1158696 (S.P.), and GNT2009047 (S.P.), and by The Geok Hua Wong Charitable Trust. icddr,b is also grateful to the Governments of Bangladesh, Canada, Sweden, and the UK for providing core/unrestricted support. This work was made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS. AB was supported by a Research Training Program Scholarship from the University of Melbourne and a stipend from WEHI.